New Modified Tyrosine Amino Acid Comprising Substituted 2-Methyl-3-Phenyl-Propionic Acid Compounds, Useful in Synthetic Peptide and Array, for Detecting Hydrolase Enzyme Activity E.G. Phosphatase and EC 3.1, and Peptide Synthesis

Pamgene B.V. University of Utrecht Holding B.V. (2012) New Modified Tyrosine Amino Acid Comprising Substituted 2-Methyl-3-Phenyl-Propionic Acid Compounds, Useful in Synthetic Peptide and Array, for Detecting Hydrolase Enzyme Activity E.G. Phosphatase and EC 3.1, and Peptide Synthesis. .

Abstract

The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from -POy 2- with y equal to 2 or 3 and esters thereof, -SOZ - with z equal to 2 or 3 and esters thereof, a carbohydrate or carbohydrate derivatives; and; wherein X1 and/or X2 is selected from -N3, -NO2, -CI, or -CN, -SCN, a C1 to C8 alkyl, or H, wherein either X1 or X2 is not H.

• Item Type: Patents
• Additional Information: Patent Number: WO2012159997-A1
• Status: Published
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Ruijtenbeek, R., Van Ameijde, J., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry

Related URLs

• Organisation