Chemical approaches for localization, characterization and mimicry of peptide epitopes

Werkhoven, P. R. and Liskamp, R. M.J. (2013) Chemical approaches for localization, characterization and mimicry of peptide epitopes. In: Jones, L. H. and McKnight, A. J. (eds.) Biotherapeutics: Recent Developments using Chemical and Molecular Biology. Series: RSC Drug Discovery Series (36). The Royal Society of Chemistry: Cambridge, pp. 263-284. ISBN 9781849736015 (doi: 10.1039/9781849737159)

Abstract

Nowadays, the designation “peptide epitope” relates to peptide segments, which are essential in protein–protein interactions. The ability to adequately mimic these epitopes will open up an abundance of important applications, varying from interference with undesired protein–protein interactions to the development of protein mimics as synthetic vaccines and, ultimately, synthetic antibodies. Crucial for mimicry of peptide epitopes is not only finding these protein–protein interaction sites, but also establishing their relative positioning, molecular details and (spatial) structure. These data are required for design, synthesis and evaluation of molecular constructs capable of this mimicry. Important challenges in this respect are, for example, adequate spacing and positioning of incorporated cyclic peptides using molecular scaffolds, which have hardly been touched, but will be extremely important for proper structural mimicry of discontinuous epitopes.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Werkhoven, P. R., and Liskamp, R. M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Publisher: The Royal Society of Chemistry
• ISBN: 9781849736015