Carrick, D. et al. (2014) A randomized trial of deferred stenting versus immediate stenting to prevent no- or slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI). Journal of the American College of Cardiology, 63(20), pp. 2088-2098. (doi: 10.1016/j.jacc.2014.02.530) (PMID:24583294) (PMCID:PMC4029071)
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Abstract
Objectives: The aim of this study was to assess whether deferred stenting might reduce no-reflow and salvage myocardium in primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Background: No-reflow is associated with adverse outcomes in STEMI. Methods: This was a prospective, single-center, randomized, controlled, proof-of-concept trial in reperfused STEMI patients with ≥1 risk factors for no-reflow. Randomization was to deferred stenting with an intention-to-stent 4 to 16 h later or conventional treatment with immediate stenting. The primary outcome was the incidence of no-/slow-reflow (Thrombolysis In Myocardial Infarction ≤2). Cardiac magnetic resonance imaging was performed 2 days and 6 months after myocardial infarction. Myocardial salvage was the final infarct size indexed to the initial area at risk. Results: Of 411 STEMI patients (March 11, 2012 to November 21, 2012), 101 patients (mean age, 60 years; 69% male) were randomized (52 to the deferred stenting group, 49 to the immediate stenting). The median (interquartile range [IQR]) time to the second procedure in the deferred stenting group was 9 h (IQR: 6 to 12 h). Fewer patients in the deferred stenting group had no-/slow-reflow (14 [29%] vs. 3 [6%]; p = 0.006), no reflow (7 [14%] vs. 1 [2%]; p = 0.052) and intraprocedural thrombotic events (16 [33%] vs. 5 [10%]; p = 0.010). Thrombolysis In Myocardial Infarction coronary flow grades at the end of PCI were higher in the deferred stenting group (p = 0.018). Recurrent STEMI occurred in 2 patients in the deferred stenting group before the second procedure. Myocardial salvage index at 6 months was greater in the deferred stenting group (68 [IQR: 54% to 82%] vs. 56 [IQR: 31% to 72%]; p = 0.031]. Conclusions: In high-risk STEMI patients, deferred stenting in primary PCI reduced no-reflow and increased myocardial salvage.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Carrick, Dr David and Rae, Dr Alan and Hood, Dr Stuart and Eteiba, Professor Hany and Petrie, Professor Mark and Layland, Dr Jamie and Oldroyd, Dr Keith and Ford, Professor Ian and Berry, Professor Colin and Haig, Dr Caroline and Mordi, Dr Ify |
| Authors: | Carrick, D., Oldroyd, K., McEntegart, M., Haig, C., Petrie, M. C., Eteiba, H., Hood, S., Owens, C., Watkins, S., Layland, J., Lindsay, M., Peat, E., Rae, A., Behan, M., Sood, A., Hillis, S., Mordi, I., Mahrous, A., Ahmed, N., Wilson, R., Lasalle, L., Généreux, P., Ford, I., and Berry, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of the American College of Cardiology |
| Journal Abbr.: | J. Am. Coll. Cardiol. |
| Publisher: | Elsevier |
| ISSN: | 0735-1097 |
| ISSN (Online): | 1558-3597 |
| Copyright Holders: | Copyright © 2014 American College of Cardiology Foundation |
| First Published: | First published in Journal of the American College of Cardiology 63(20):2088-2098 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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