Cholinergic modulation of hippocampal cells and circuits

Cobb, S.R. and Davies, C.H. (2005) Cholinergic modulation of hippocampal cells and circuits. Journal of Physiology, 562(1), pp. 81-88. (doi:10.1113/jphysiol.2004.076539)

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Septo-hippocampal cholinergic fibres ramify extensively throughout the hippocampal formation to release acetylcholine upon a diverse range of muscarinic and nicotinic acetylcholine receptors that are differentially expressed by distinct populations of neurones. The resultant modulation of cellular excitability and synaptic transmission within hippocampal circuits underlies the ability of acetylcholine to influence the dynamic properties of the hippocampal network and results in the emergence of a range of stable oscillatory network states. Recent findings suggest a multitude of actions contribute to the oscillogenic properties of acetylcholine which are principally induced by activation of muscarinic receptors but also regulated through activation of nicotinic receptor subtypes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cobb, Dr Stuart
Authors: Cobb, S.R., and Davies, C.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Physiology
ISSN (Online):1469-7793
Published Online:04 November 2004

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