Compartmentalisation of second messenger signalling pathways

McCormick, K. and Baillie, G. S. (2014) Compartmentalisation of second messenger signalling pathways. Current Opinion in Genetics and Development, 27, pp. 20-25. (doi:10.1016/j.gde.2014.02.001)

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Publisher's URL: http://dx.doi.org/10.1016/j.gde.2014.02.001

Abstract

The ability of a cell to transform an extracellular stimulus into a downstream event that directs specific physiological outcomes, requires the orchestrated, spatial and temporal response of many signalling proteins. The notion of compartmentalised signalling pathways was popularised in the 1980s by Brunton and colleagues, with their discovery that spatially segregated cAMP directs a variety of signalling responses in cardiomyocytes. It is now understood that compartmentalisation is a common mechanism used by all cells to ensure the interaction of signalling ‘second messenger’ molecules with localised ‘pools’ of appropriate effector proteins. In this way, the cell can elicit differential cellular responses by using a single, freely diffusible, molecular species. Recently, the compartmentalisation schemes employed by signalling systems involving cyclic nucleotides, calcium and nitric oxide have been elucidated and as a result, the varied range of functional consequences underpinned by such strategies can be better appreciated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George
Authors: McCormick, K., and Baillie, G. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Current Opinion in Genetics and Development
Publisher:Elsevier
ISSN:0959-437X
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
582921Development of small molecules that induce the cardio-protective effects of HSP20George BaillieHeart Research UK (HEART-RES)RG2610/12/14RI CARDIOVASCULAR & MEDICAL SCIENCES