The inner membrane complex through development of Toxoplasma gondii and Plasmodium

Harding, C. R. and Meissner, M. (2014) The inner membrane complex through development of Toxoplasma gondii and Plasmodium. Cellular Microbiology, 16(5), pp. 632-641. (doi:10.1111/cmi.12285)

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Abstract

Plasmodium spp. and Toxoplasma gondii are important human and veterinary pathogens. These parasites possess an unusual double membrane structure located directly below the plasma membrane named the inner membrane complex (IMC). First identified in early electron micrograph studies, huge advances in genetic manipulation of the Apicomplexa have allowed the visualization of a dynamic, highly structured cellular compartment with important roles in maintaining the structure and motility of these parasites. This review summarizes recent advances in the field and highlights the changes the IMC undergoes during the complex life cycles of the Apicomplexa.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Meissner, Professor Markus and Harding, Dr Clare
Authors: Harding, C. R., and Meissner, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Microbiology
Publisher:Wiley-Blackwell Publishing
ISSN:1462-5814
ISSN (Online):1462-5822
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Cellular Microbiology 16(5):632-641
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
501601Systematic analysis of essential parasite genes linked to invasion of the host cell in Toxoplasma gondiiMarkus MeissnerWellcome Trust (WELLCOME)087582/Z/08/ZIII - PARASITOLOGY