Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

Zhang, J., Kemmink, J., Rijkers, D. T. S. and Liskamp, R. M. J. (2013) Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization. Chemical Communications, 49(40), pp. 4498-4500. (doi:10.1039/c3cc40628h)

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Publisher's URL: http://dx.doi.org/10.1039/c3cc40628h

Abstract

Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of vancomycin, followed by measurement of its binding affinity for small peptide ligands using ITC.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Zhang, J., Kemmink, J., Rijkers, D. T. S., and Liskamp, R. M. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Journal Abbr.:Chem. Comm.
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X

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