van de Langemheen, H., Quarles van Ufford, H. (L.) C., Kruijtzer, J. A. W. and Liskamp, R. M.J. (2014) Efficient synthesis of protein mimics by sequential native chemical ligation. Organic Letters, 16(8), pp. 2138-2141. (doi: 10.1021/ol500604h)
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Publisher's URL: http://dx.doi.org/10.1021/ol500604h
Abstract
Synthetic mimics of protein surfaces have the potential to become inhibitors of protein–protein interactions or even synthetic vaccines. However, the synthesis of these complicated molecular constructs is still difficult. Here we describe an efficient and versatile synthesis of protein mimics containing up to three different cyclic peptides. Using a sequential native chemical ligation strategy, peptide loops containing a thioester handle were introduced onto a triazacyclophane scaffold bearing orthogonal protected cysteine residues.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | van de Langemheen, H., Quarles van Ufford, H. (L.) C., Kruijtzer, J. A. W., and Liskamp, R. M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Organic Letters |
Journal Abbr.: | Org. Lett. |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
ISSN (Online): | 1523-7052 |
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