Efficient synthesis of protein mimics by sequential native chemical ligation

van de Langemheen, H., Quarles van Ufford, H. (L.) C., Kruijtzer, J. A. W. and Liskamp, R. M.J. (2014) Efficient synthesis of protein mimics by sequential native chemical ligation. Organic Letters, 16(8), pp. 2138-2141. (doi:10.1021/ol500604h)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1021/ol500604h

Abstract

Synthetic mimics of protein surfaces have the potential to become inhibitors of protein–protein interactions or even synthetic vaccines. However, the synthesis of these complicated molecular constructs is still difficult. Here we describe an efficient and versatile synthesis of protein mimics containing up to three different cyclic peptides. Using a sequential native chemical ligation strategy, peptide loops containing a thioester handle were introduced onto a triazacyclophane scaffold bearing orthogonal protected cysteine residues.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: van de Langemheen, H., Quarles van Ufford, H. (L.) C., Kruijtzer, J. A. W., and Liskamp, R. M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic Letters
Journal Abbr.:Org. Lett.
Publisher:American Chemical Society
ISSN:1523-7060
ISSN (Online):1523-7052

University Staff: Request a correction | Enlighten Editors: Update this record