The monocyte-macrophage axis in the intestine

Bain, C. C. and Mowat, A. M. (2014) The monocyte-macrophage axis in the intestine. Cellular Immunology, 291(1-2), pp. 41-48. (doi: 10.1016/j.cellimm.2014.03.012)

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Publisher's URL: http://dx.doi.org/10.1016/j.cellimm.2014.03.012

Abstract

Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mowat, Professor Allan and Bain, Mr Calum
Authors: Bain, C. C., and Mowat, A. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Immunology
Publisher:Elsevier
ISSN:0008-8749
ISSN (Online):1090-2163
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Cellular Immunology 291(1-2):41-48
Publisher Policy:Reproduced under a Creative Commons License
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