Bain, C. C. and Mowat, A. M. (2014) Macrophages in intestinal homeostasis and inflammation. Immunological Reviews, 260(1), pp. 102-117. (doi: 10.1111/imr.12192)
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Abstract
The intestine contains the largest pool of macrophages in the body which are essential for maintaining mucosal homeostasis in the face of the microbiota and the constant need for epithelial renewal but are also important components of protective immunity and are involved in the pathology of inflammatory bowel disease (IBD). However, defining the biological roles of intestinal macrophages has been impeded by problems in defining the phenotype and origins of different populations of myeloid cells in the mucosa. Here, we discuss how multiple parameters can be used in combination to discriminate between functionally distinct myeloid cells and discuss the roles of macrophages during homeostasis and how these may change when inflammation ensues. We also discuss the evidence that intestinal macrophages do not fit the current paradigm that tissue-resident macrophages are derived from embryonic precursors that self-renew in situ, but require constant replenishment by blood monocytes. We describe our recent work demonstrating that classical monocytes constantly enter the intestinal mucosa and how the environment dictates their subsequent fate. We believe that understanding the factors that drive intestinal macrophage development in the steady state and how these may change in response to pathogens or inflammation could provide important insights into the treatment of IBD.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mowat, Professor Allan and Bain, Mr Calum |
| Authors: | Bain, C. C., and Mowat, A. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Immunological Reviews |
| Publisher: | John Wiley and Sons |
| ISSN: | 0105-2896 |
| ISSN (Online): | 1600-065X |
| Copyright Holders: | Copyright © 2014 The Authors |
| First Published: | First published in Immunological Reviews 260 (1):102-117 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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