Quasi-static imaged-based immersed boundary-finite element model of human left ventricle in diastole

Gao, H. , Wang, H., Berry, C. , Luo, X. and Griffith, B. E. (2014) Quasi-static imaged-based immersed boundary-finite element model of human left ventricle in diastole. International Journal for Numerical Methods in Biomedical Engineering, 30(11), pp. 1199-1222. (doi: 10.1002/cnm.2652)

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Publisher's URL: http://dx.doi.org/10.1002/cnm.2652


SUMMARY: Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure-based hyperelastic strain-energy function to describe the passive mechanics of the ventricular myocardium, a realistic anatomical geometry reconstructed from clinical magnetic resonance images of a healthy human heart, and a rule-based fiber architecture. Numerical predictions of this IB/FE model are compared with results obtained by a commercial FE solver. We demonstrate that the IB/FE model yields results that are in good agreement with those of the conventional FE model under diastolic loading conditions, and the predictions of the LV model using either numerical method are shown to be consistent with previous computational and experimental data. These results are among the first to analyze the stress and strain predictions of IB models of ventricular mechanics, and they serve both to verify the IB/FE simulation framework and to validate the IB/FE model. Moreover, this work represents an important step toward using such models for fully dynamic fluid–structure interaction simulations of the heart.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Wang, Mr HuiMing and Griffith, Dr Boyce and Gao, Dr Hao and Berry, Professor Colin
Authors: Gao, H., Wang, H., Berry, C., Luo, X., and Griffith, B. E.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:International Journal for Numerical Methods in Biomedical Engineering
Publisher:John Wiley & Sons Ltd.
ISSN (Online):2040-7947
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in International Journal for Numerical Methods in Biomedical Engineering 30(11):1199-1222
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
560111Finite element-immersed boundary method and its application to mitral valvesXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/I029990/1M&S - MATHEMATICS