Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: solution- and solid-phase approaches

Yvon, C., Surman, A. J. , Hutin, M., Alex, J., Smith, B. O. , Long, D. L. and Cronin, L. (2014) Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: solution- and solid-phase approaches. Angewandte Chemie (International Edition), 53(13), pp. 3336-3341. (doi:10.1002/anie.201311135)

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Abstract

General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution-phase approach, pre-synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid-phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain “inorganic” amino acids.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hutin, Dr Marie and Smith, Dr Brian and Long, Dr De Liang and Cronin, Professor Leroy and Surman, Dr Andrew and Yvon, Miss Carine
Authors: Yvon, C., Surman, A. J., Hutin, M., Alex, J., Smith, B. O., Long, D. L., and Cronin, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1433-7851
ISSN (Online):1521-3773

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