One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds

Calder, E. D.D., Grafton, M. W. and Sutherland, A. (2014) One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds. Synlett, 25(8), pp. 1068-1080. (doi: 10.1055/s-0033-1340683)

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Publisher's URL: http://dx.doi.org/10.1055/s-0033-1340683

Abstract

One-pot multi-reaction processes involving Overman rearrangements, metathesis cyclizations, and Diels–Alder reactions have been developed for the rapid and efficient synthesis of amino-substituted carbocyclic and heterocyclic compounds. This account describes the development and optimization of these processes, as well as their applications in the synthesis of natural products and drug-like scaffolds.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Grafton, Mr Mark and Sutherland, Professor Andrew and Calder, Mr Ewen
Authors: Calder, E. D.D., Grafton, M. W., and Sutherland, A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Synlett
Publisher:Thieme Publishing
ISSN:0936-5214
ISSN (Online):1437-2096
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Synlett 25(8):1068-1080
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
554791EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE
554792EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE
554793EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE
554794EPSRC Doctoral Training Grant 2010-14Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/P505534/1VICE PRINCIPAL RESEARCH & ENTERPRISE