The search for novel analgesics: re-examining spinal cord circuits with new tools

Smith, K. M., Madden, J. F., Callister, R. J., Hughes, D. I. and Graham, B. A. (2014) The search for novel analgesics: re-examining spinal cord circuits with new tools. Frontiers in Pharmacology, 5(22), pp. 1-6. (doi:10.3389/fphar.2014.00022) (PMID:24616699) (PMCID:PMC3934318)

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Publisher's URL: http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00022/abstract

Abstract

In this perspective, we propose the absence of detailed information regarding spinal cord circuits that process sensory information remains a major barrier to advancing analgesia. We highlight recent advances showing that functionally discrete populations of neurons in the spinal cord dorsal horn play distinct roles in processing sensory information. We then discuss new molecular, electrophysiological, and optogenetic techniques that can be employed to understand how dorsal horn circuits process tactile and nociceptive information. We believe this information can drive the development of entirely new classes of pharmacotherapies that target key elements in spinal circuits to selectively modify sensory function and blunt pain.

Item Type:Articles (Other)
Keywords:dorsal horn, interneuron, optogenetics, genetic profiling
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hughes, Dr David I and Smith, Miss Kelly
Authors: Smith, K. M., Madden, J. F., Callister, R. J., Hughes, D. I., and Graham, B. A.
Subjects:Q Science > QP Physiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Research Group:Dr David I Hughes
Journal Name:Frontiers in Pharmacology
Journal Abbr.:Front. Pharmacol.
Publisher:Frontiers Research Foundation
ISSN:1663-9812
ISSN (Online):1663-9812
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Frontiers in Pharmacology 5(22):1-6
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
571071Modulating cutaneous afferent input: Identifying a source of presynaptic (axo-axonic) inputs in the mouse spinal dorsal hornDavid I HughesBiotechnology and Biological Sciences Research Council (BBSRC)BB/J000620/1RI NEUROSCIENCE & PSYCHOLOGY