Type 2 innate lymphoid cells drive CD4+ Th2 cell responses

Mirchandani, A. S., Besnard, A.-G., Yip, E., Scott, C., Bain, C. C., Cerovic, V., Salmond, R. J. and Liew, F. J. (2014) Type 2 innate lymphoid cells drive CD4+ Th2 cell responses. Journal of Immunology, 192(5), pp. 2442-2448. (doi: 10.4049/jimmunol.1300974)

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Abstract

CD4+ T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate lymphoid cell have been described as key producers of these same Th-associated cytokines. However, the functional relationship between Th cells and innate lymphoid cells (ILCs) remains unclear. We show in this study that lineage-negative ST2+ICOS+CD45+ type 2 ILCs and CD4+ T cells can potently stimulate each other’s function via distinct mechanisms. CD4+ T cell provision of IL-2 stimulates type 2 cytokine production by type 2 ILCs. By contrast, type 2 ILCs modulate naive T cell activation in a cell contact–dependent manner, favoring Th2 while suppressing Th1 differentiation. Furthermore, a proportion of type 2 ILCs express MHC class II and can present peptide Ag in vitro. Importantly, cotransfer experiments show that type 2 ILCs also can boost CD4+ T cell responses to Ag in vivo.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liew, Prof Foo and Mirchandani, Dr Ananda and Besnard, Dr Anne-Gaelle and Yip, Mr Edwin and Cerovic, Dr Vuk and Bain, Mr Calum and Salmond, Dr Robert
Authors: Mirchandani, A. S., Besnard, A.-G., Yip, E., Scott, C., Bain, C. C., Cerovic, V., Salmond, R. J., and Liew, F. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
Publisher:American Association of Immunologists
ISSN:0022-1767
ISSN (Online):1550-6606
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