Baker, K.S. et al. (2014) Viral antibody dynamics in a chiropteran host. Journal of Animal Ecology, 83(2), pp. 415-428. (doi: 10.1111/1365-2656.12153) (PMID:24111634)
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Abstract
1. Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated.<p></p> 2. In these, and other, systems, there is evidence that seasonal life-cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts.<p></p> 3. To this end, we followed henipavirus antibody levels of >100 individual E. helvum in a closed, captive, breeding population over a 30-month period, using a powerful novel antibody quantitation method.<p></p> 4. We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population-level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period.<p></p> 5.The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half-life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Murcia, Professor Pablo |
Authors: | Baker, K.S., Suu-Ire, R., Barr, J., Hayman, D.T.S., Broder, C.C., Horton, D.L., Durrant, C., Murcia, P.R., Cunningham, A.A., Wood, J.L.N., and Boots, M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of Animal Ecology |
Publisher: | John Wiley & Sons Ltd. |
ISSN: | 0021-8790 |
ISSN (Online): | 1365-2656 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in Journal of Animal Ecology 82(2):415-428 |
Publisher Policy: | Reproduced under a Creative Commons License |
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