Translational perspectives on perfusion-diffusion mismatch in ischemic stroke

Campbell, B. C. V. and Macrae, I. M. (2014) Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. International Journal of Stroke, 10(2), pp. 153-162. (doi:10.1111/ijs.12186)

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Abstract

Magnetic resonance imaging has tremendous potential to illuminate ischemic stroke pathophysiology and guide rational treatment decisions. Clinical applications to date have been largely limited to trials. However, recent analyses of the major clinical studies have led to refinements in selection criteria and improved understanding of the potential implications for the risk vs. benefit of thrombolytic therapy. In parallel, preclinical studies have provided complementary information on the evolution of stroke that is difficult to obtain in humans due to the requirement for continuous or repeated imaging and pathological verification. We review the clinical and preclinical advances that have led to perfusion–diffusion mismatch being applied in phase 3 randomized trials and, potentially, future routine clinical practice.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macrae, Professor I Mhairi
Authors: Campbell, B. C. V., and Macrae, I. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:International Journal of Stroke
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:1747-4930
ISSN (Online):1747-4949
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in the International Journal of Stroke 10(2):153-162
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
455001Imaging the ischaemic penumbra using BOLD MRI with oxygen challenge as a biotracerI Mhairi MacraeMedical Research Council (MRC)G0700439RI NEUROSCIENCE & PSYCHOLOGY