Campbell, B. C. V. and Macrae, I. M. (2014) Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. International Journal of Stroke, 10(2), pp. 153-162. (doi: 10.1111/ijs.12186)
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Abstract
Magnetic resonance imaging has tremendous potential to illuminate ischemic stroke pathophysiology and guide rational treatment decisions. Clinical applications to date have been largely limited to trials. However, recent analyses of the major clinical studies have led to refinements in selection criteria and improved understanding of the potential implications for the risk vs. benefit of thrombolytic therapy. In parallel, preclinical studies have provided complementary information on the evolution of stroke that is difficult to obtain in humans due to the requirement for continuous or repeated imaging and pathological verification. We review the clinical and preclinical advances that have led to perfusion–diffusion mismatch being applied in phase 3 randomized trials and, potentially, future routine clinical practice.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Macrae, Professor Mhairi |
| Authors: | Campbell, B. C. V., and Macrae, I. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | International Journal of Stroke |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 1747-4930 |
| ISSN (Online): | 1747-4949 |
| Copyright Holders: | Copyright © 2013 The Authors |
| First Published: | First published in the International Journal of Stroke 10(2):153-162 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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