Light path-length distributions within the retina

Rodmell, P. I., Crowe, J. A., Gorman, A., Harvey, A. R. , Muyo, G., Mordant, D. J., McNaught, A. I. and Morgan, S. P. (2014) Light path-length distributions within the retina. Journal of Biomedical Optics, 19(3), 036008. (doi: 10.1117/1.JBO.19.3.036008)

Abstract

A Monte Carlo simulation of light propagation through the retina has been developed to understand the path-length distributions within the retinal vessel. For full-field illumination, the path-length distribution within the vessel comprises directly backscattered light and light that has passed once or twice through the vessel. The origins of these light path-length distributions can be better understood by investigating different combinations of single-point illumination and detection positions. Perhaps the most significant observation is that illumination at the edges of the vessel, rather than over the whole field of view, and detection directly above the vessel capture only the light that has taken a single pass through the vessel. This path-length distribution is tightly constrained around the diameter of the vessel and can potentially provide enhancements for oxygen saturation imaging. The method could be practically implemented using an offset-pinhole confocal imaging system or structured light illumination.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gorman, Dr Alistair and Harvey, Professor Andy
• Authors: Rodmell, P. I., Crowe, J. A., Gorman, A., Harvey, A. R., Muyo, G., Mordant, D. J., McNaught, A. I., and Morgan, S. P.
• College/School: College of Science and Engineering > School of Physics and Astronomy
• Journal Name: Journal of Biomedical Optics
• Publisher: Society of Photo-Optical Instrumentation Engineers
• ISSN: 1083-3668
• ISSN (Online): 1560-2281
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in Journal of Biomedical Optics 19(3):036008
• Publisher Policy: Reproduced under a Creative Commons License