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Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population

Hutchinson, W.L., Koenig, W., Frohlich, M., Sund, M., Lowe, G.D.O., and Pepys, M.B. (2000) Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population. Clinical Chemistry, 46 (7). pp. 934-938. ISSN 0009-9147

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Publisher's URL: http://www.clinchem.org/cgi/content/abstract/46/7/934

Abstract

Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection.
Methods: A robust new polyclonal-monoclonal solid-phase IRMA for CRP was developed, with a range of 0.05- 10.0 mg/L.
Results: Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25-74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25-64 years) were very similar. The median CRP approximately doubled with age, from similar to 1 mg/L in the youngest decade to similar to 2 mg/L in the oldest, and tended to be higher in females.
Conclusion: This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lowe, Prof Gordon
Authors: Hutchinson, W.L., Koenig, W., Frohlich, M., Sund, M., Lowe, G.D.O., and Pepys, M.B.
Subjects:R Medicine > RB Pathology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences > Cardiovascular Science
Journal Name:Clinical Chemistry
Publisher:American Association for Clinical Chemistry
ISSN:0009-9147
Copyright Holders:© Copyright 2003 American Association for Clinical Chemistry, Inc.
First Published:First published in Clinical Chemistry 46(7):934-938
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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