Wilcox, M. H., Smith, D. G.E., Evans, J. A., Denyer, S. P., Finch, R. G. and Williams, P. (1990) Influence of carbon dioxide on growth and antibiotic susceptibility of coagulase-negative staphylococci cultured in human peritoneal dialysate. Journal of Clinical Microbiology, 28(10), pp. 2183-6.
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Publisher's URL: http://jcm.asm.org/content/28/10/2183
Abstract
Used peritoneal dialysis fluid was collected from patients undergoing continuous ambulatory peritoneal dialysis, and its pH and composition were assessed after incubation in either air or air with 5% CO2. Precipitation of calcium, magnesium, phosphate, and proteins occurred in the dialysis fluid incubated in air at 37 degrees C and was associated with a mean pH increase of 1.23 U. Incubation of dialysis fluid in air with 5% CO2 prevented precipitation and maintained pCO2 and pH levels at those found physiologically. Coagulase-negative staphylococcal strains isolated from patients with peritonitis tended to grow less well in dialysis fluid incubated in air than in dialysis fluid incubated in the carbon dioxide-enriched atmosphere. MICs of cefuroxime, ciprofloxacin, and vancomycin for seven strains of coagulase-negative staphylococci in dialysis fluid were markedly affected by atmosphere type (16 of 21 MICs). Of these 16 atmosphere-dependent MICs, 14 were at least fourfold higher in air than in air with 5% CO2.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Smith, Professor David |
Authors: | Wilcox, M. H., Smith, D. G.E., Evans, J. A., Denyer, S. P., Finch, R. G., and Williams, P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Clinical Microbiology |
Publisher: | American Society for Microbiology |
ISSN: | 0095-1137 |
ISSN (Online): | 1098-660X |
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