Rac1 drives intestinal stem cell proliferation and regeneration

Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J. and Cordero, J.B. (2013) Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle, 12(18), pp. 2973-2977. (doi:10.4161/cc.26031)

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Publisher's URL: http://dx.doi.org/10.4161/cc.26031

Abstract

Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood. The production of reactive oxygen species (ROS) has emerged as an important mediator of stem cell homeostasis in various systems. Our recent work demonstrates that Rac1-dependent ROS production mediates intestinal stem cell (ISC) proliferation in mouse models of colorectal cancer (CRC). Here, we use the adult Drosophila midgut and the mouse small intestine to directly address the role of Rac1 in ISC proliferation and tissue regeneration in response to damage. Our results demonstrate that Rac1 is necessary and sufficient to drive ISC proliferation and regeneration in an ROS-dependent manner. Our data point to an evolutionarily conserved role of Rac1 in intestinal homeostasis and highlight the value of combining work in the mammalian and Drosophila intestine as paradigms to study stem cell biology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vidal, Dr Marcos and Cordero, Dr Julia and Myant, Dr Kevin and Sansom, Professor Owen and Scopelliti, Mr Alessandro
Authors: Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J., and Cordero, J.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Cycle
Publisher:Landes Bioscience
ISSN:1538-4101
ISSN (Online):1551-4005
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Cell Cycle 12(18):2973-2977
Publisher Policy:Reproduced under a Creative Commons License

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