Role for mannose binding lectin in the prevention of mycoplasma infection

Hamvas, R.M.J., Johnson, M., Vlieger, A.M., Ling, C., Sherriff, A. , Wade, A., Klein, N.J., Turner, M.W. and Webster, A.D.B. (2005) Role for mannose binding lectin in the prevention of mycoplasma infection. Infection and Immunity, 73(8), pp. 5238-5240. (doi:10.1128/IAI.73.8.5238-5240.2005)

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Publisher's URL: http://dx.doi.org/10.1128/IAI.73.8.5238-5240.2005

Abstract

Polymorphisms in exon 1 of the MBL-2 gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P = 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P = 0.0087). The lectin was shown to bind to three strains of mycoplasma.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sherriff, Dr Andrea
Authors: Hamvas, R.M.J., Johnson, M., Vlieger, A.M., Ling, C., Sherriff, A., Wade, A., Klein, N.J., Turner, M.W., and Webster, A.D.B.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Infection and Immunity
Journal Abbr.:IAI
Publisher:American Society for Microbiology
ISSN:0019-9567
ISSN (Online):1098-5522
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