Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh artery study

Fowkes, F.G.R., Lee, A.J., Hau, C.M., Cooke, A., Connor, J.M., and Lowe, G.D.O. (2000) Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh artery study. Atherosclerosis, 150 (1). pp. 179-185. ISSN 0021-9150 (doi:10.1016/S0021-9150(99)00366-4)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1016/S0021-9150(99)00366-4

Abstract

Hyperhomocysteinaemia and reduced nitric oxide synthesis may each result in endothelial dysfunction predisposing to atherogenesis. Genetic variants of methylene tetrahydrofolate reductase (MTHFR) and endothelial nitric oxide synthase (ecNOS) influence homocysteine metabolism and nitric oxide synthesis, respectively and might thus be determinants of the risk of atherosclerotic disease. The aim of our study was to identify, in a general population sample, the risks of peripheral arterial disease and of coronary heart disease related to MTHFR (175;198) and ecNOS (4;5) polymorphisms. In the Edinburgh Artery Study, which is a population based cohort study, 940 men and women aged 60-79 years, who had previously been selected at random from the general population, had DNA extracted from a venous blood sample. Based on a clinical examination at baseline and follow up investigations, three groups of subjects were identified: those with peripheral arterial disease (n = 80), those with coronary heart disease (n = 137), and healthy controls who had no evidence of cardiovascular disease (n = 300). The distributions of the ecNOS and MTHFR genotypes did not differ significantly between the groups with and without cardiovascular disease. However, the ecNOS-4 allele (frequency 0.13) was related to the occurrence of coronary heart disease in non smokers, OR = 2.47 (95% CI [1.42, 4.34], P = 0.02). No association was found with peripheral arterial disease. The MTHFR-175 allele (frequency 0.31) was not related to coronary heart disease, but was associated with a reduced risk of peripheral arterial disease, OR = 0.54 (95% CI [0.32, 0.90], P = 0.02). Neither the ecNOS-4 allele or MTHFR-175 allele was related to the ankle brachial pressure index in the whole study population. In conclusion, the ecNOS-4 allele was associated with a slightly increased risk of coronary heart disease in non-smokers, but otherwise the MTHFR and ecNOS genotypes appeared to have little influence on the risks of peripheral arterial disease and coronary heart disease in this older population.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Connor, Dr John and Cooke, Dr Alexander and Lowe, Prof Gordon
Authors: Fowkes, F.G.R., Lee, A.J., Hau, C.M., Cooke, A., Connor, J.M., and Lowe, G.D.O.
Subjects:R Medicine > RC Internal medicine
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences > Cardiovascular Science
Journal Name:Atherosclerosis
Publisher:Elsevier Ireland Ltd
ISSN:0021-9150
ISSN (Online):1879-1484

University Staff: Request a correction | Enlighten Editors: Update this record