On the neural origin of pseudoneglect: EEG-correlates of shifts in line bisection performance with manipulation of line length

Benwell, C. S.Y., Harvey, M. and Thut, G. (2014) On the neural origin of pseudoneglect: EEG-correlates of shifts in line bisection performance with manipulation of line length. NeuroImage, 86, pp. 370-380. (doi:10.1016/j.neuroimage.2013.10.014) (PMID:24128738) (PMCID:PMC3980346)

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Abstract

Healthy participants tend to show systematic biases in spatial attention, usually to the left. However, these biases can shift rightward as a result of a number of experimental manipulations. Using electroencephalography (EEG) and a computerized line bisection task, here we investigated for the first time the neural correlates of changes in spatial attention bias induced by line-length (the so-called line-length effect). In accordance with previous studies, an overall systematic left bias (pseudoneglect) was present during long line but not during short line bisection performance. This effect of line-length on behavioral bias was associated with stronger right parieto-occipital responses to long as compared to short lines in an early time window (100–200 ms) post-stimulus onset. This early differential activation to long as compared to short lines was task-independent (present even in a non-spatial control task not requiring line bisection), suggesting that it reflects a reflexive attentional response to long lines. This was corroborated by further analyses source-localizing the line-length effect to the right temporo-parietal junction (TPJ) and revealing a positive correlation between the strength of this effect and the magnitude by which long lines (relative to short lines) drive a behavioral left bias across individuals. Therefore, stimulus-driven left bisection bias was associated with increased right hemispheric engagement of areas of the ventral attention network. This further substantiates that this network plays a key role in the genesis of spatial bias, and suggests that post-stimulus TPJ-activity at early information processing stages (around the latency of the N1 component) contributes to the left bias.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Benwell, Mr Christopher and Thut, Professor Gregor and Harvey, Dr Monika
Authors: Benwell, C. S.Y., Harvey, M., and Thut, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Science and Engineering > School of Psychology
Journal Name:NeuroImage
Publisher:Elsevier Inc.
ISSN:1053-8119
ISSN (Online):1095-9572
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in NeuroImage 86:370-380
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
597911Natural and modulated neural communication: State-dependent decoding and driving of human Brain OscillationsGregor ThutWellcome Trust (WELLCOME)098434/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING