Branching out to gain control: how the pre-TCR is linked to multiple functions

Kruisbeek, A. M., Haks, M. C., Carleton, M., Wiest, D. L., Michie, A. M. and Zúñiga-Pflücker, J. C. (2000) Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunology Today, 21(12), pp. 637-644. (doi: 10.1016/S0167-5699(00)01744-8)

Abstract

How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Michie, Professor Alison
• Authors: Kruisbeek, A. M., Haks, M. C., Carleton, M., Wiest, D. L., Michie, A. M., and Zúñiga-Pflücker, J. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Immunology Today
• ISSN: 0167-5699
• ISSN (Online): 1355-8242