Branching out to gain control: how the pre-TCR is linked to multiple functions

Kruisbeek, A. M., Haks, M. C., Carleton, M., Wiest, D. L., Michie, A. M. and Zúñiga-Pflücker, J. C. (2000) Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunology Today, 21(12), pp. 637-644. (doi:10.1016/S0167-5699(00)01744-8)

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Abstract

How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Michie, Dr Alison
Authors: Kruisbeek, A. M., Haks, M. C., Carleton, M., Wiest, D. L., Michie, A. M., and Zúñiga-Pflücker, J. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Immunology Today
ISSN:0167-5699
ISSN (Online):1355-8242

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