Clonal characterization of a bipotent T cell and Natural Killer cell progenitor in the mouse fetal thymus

Michie, A. M. , Carlyle, J. R., Schmitt, T. M., Ljutic, B., Cho, S. K., Fong, Q. and Zúñiga-Pflücker, J. C. (2000) Clonal characterization of a bipotent T cell and Natural Killer cell progenitor in the mouse fetal thymus. Journal of Immunology, 164(4), pp. 1730-1733.

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Publisher's URL: http://www.jimmunol.org/content/164/4/1730.abstract

Abstract

We recently described a population of fetal thymocytes with a CD117+NK1.1+CD90lowCD25− phenotype, which were shown to contain committed T cell and NK cell progenitors. However, the characterization of a single cell with a restricted T and NK cell precursor potential was lacking. Here, using an in vitro model for T and NK cell differentiation, we provide conclusive evidence demonstrating the existence of a clonal lineage-restricted T and NK cell progenitor. These results establish that fetal thymocytes with a CD117+NK1.1+CD90lowCD25− phenotype represent bipotent T and NK cell progenitors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Michie, Dr Alison
Authors: Michie, A. M., Carlyle, J. R., Schmitt, T. M., Ljutic, B., Cho, S. K., Fong, Q., and Zúñiga-Pflücker, J. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Immunology
ISSN:0022-1767
ISSN (Online):1872-7905

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