Michie, A. M. , Carlyle, J. R., Schmitt, T. M., Ljutic, B., Cho, S. K., Fong, Q. and Zúñiga-Pflücker, J. C. (2000) Clonal characterization of a bipotent T cell and Natural Killer cell progenitor in the mouse fetal thymus. Journal of Immunology, 164(4), pp. 1730-1733.
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Publisher's URL: http://www.jimmunol.org/content/164/4/1730.abstract
Abstract
We recently described a population of fetal thymocytes with a CD117+NK1.1+CD90lowCD25− phenotype, which were shown to contain committed T cell and NK cell progenitors. However, the characterization of a single cell with a restricted T and NK cell precursor potential was lacking. Here, using an in vitro model for T and NK cell differentiation, we provide conclusive evidence demonstrating the existence of a clonal lineage-restricted T and NK cell progenitor. These results establish that fetal thymocytes with a CD117+NK1.1+CD90lowCD25− phenotype represent bipotent T and NK cell progenitors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Michie, Professor Alison |
| Authors: | Michie, A. M., Carlyle, J. R., Schmitt, T. M., Ljutic, B., Cho, S. K., Fong, Q., and Zúñiga-Pflücker, J. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Journal of Immunology |
| ISSN: | 0022-1767 |
| ISSN (Online): | 1872-7905 |
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