Nuclear DNA replication initiation in kinetoplastid parasites: new insights into an ancient process

Tiengwe, C., Marques, C. A. and McCulloch, R. (2014) Nuclear DNA replication initiation in kinetoplastid parasites: new insights into an ancient process. Trends in Parasitology, 30(1), pp. 27-36. (doi:10.1016/

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Nuclear DNA replication is, arguably, the central cellular process in eukaryotes, because it drives propagation of life and intersects with many other genome reactions. Perhaps surprisingly, our understanding of nuclear DNA replication in kinetoplastids was limited until a clutch of studies emerged recently, revealing new insight into both the machinery and genome-wide coordination of the reaction. Here, we discuss how these studies suggest that the earliest acting components of the kinetoplastid nuclear DNA replication machinery – the factors that demarcate sites of the replication initiation, termed origins – are diverged from model eukaryotes. In addition, we discuss how origin usage and replication dynamics relate to the highly unusual organisation of transcription in the genome of Trypanosoma brucei.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McCulloch, Professor Richard and De Almeida Marques, Dr Catarina
Authors: Tiengwe, C., Marques, C. A., and McCulloch, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
ISSN (Online):1471-5007
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
463981Characterisation of Orc1/Cdc6 and DNA replication initiation in Trypanosoma brucei.Richard MccullochWellcome Trust (WELLCOME)083485/Z/07/ZIII - PARASITOLOGY
371793The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)073990/Z/03/BIII - PARASITOLOGY