The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration

Insall, R. (2013) The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration. Current Opinion in Cell Biology, 25(5), pp. 526-531. (doi:10.1016/j.ceb.2013.04.009)

Full text not currently available from Enlighten.

Abstract

Eukaryotic chemotaxis is extremely complex. Cells can sense a wide range of stimuli, and many intracellular pathways are simultaneously involved. Recent genetic analyses of the steps between receptors and cytoskeleton, and how the cell controls actin and pseudopod behaviour, have yielded exciting new data but still no coherent understanding of chemotaxis. However, concentrating on pseudopods themselves and the physical processes that regulate them, rather than the internal signalling pathways, can simplify the data and help resolve the underlying mechanism. Direct action of electric fields and physical forces on cell migration suggest that mechanical forces and force-generating proteins like actin and myosin are centrally important in steering cells during chemotaxis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Insall, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Opinion in Cell Biology
Publisher:Elsevier
ISSN:0955-0674
ISSN (Online):1879-0410

University Staff: Request a correction | Enlighten Editors: Update this record