Genome-wide association studies of hypertension: light at the end of the tunnel

Hastie, C. E., Padmanabhan, S. and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010(509581), (doi:10.4061/2010/509581)

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Abstract

Despite its significant genetic component, the study of hypertension by genome-wide association presents more challenges than other common complex diseases. Its high prevalence, heterogeneity, and somewhat unclear definition are the challenges that need to be overcome on one hand. On the other hand, there are issues of small effect sizes and pleiotropism that are not specific to hypertension alone but nonetheless magnify the problems of genetic dissection when coupled with phenotypic misclassification. We discuss issues of study design and summarise published genome-wide association studies (GWASs) of hypertension and blood pressure. With careful study design and analysis success is possible, as demonstrated by the recent large-scale studies. Following these, there is still further scope to advance the field through high fidelity phenotyping and deep sequencing.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hastie, Dr Claire and Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna
Authors: Hastie, C. E., Padmanabhan, S., and Dominiczak, A. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Hypertension
Publisher:SAGE-Hindawi Access to Research
ISSN:2090-0384
ISSN (Online):2090-0392
Copyright Holders:Copyright © 2010 The Authors
First Published:First published in International Journal of Hypertension 2010:509581
Publisher Policy:Reproduced under a Creative Commons License

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