Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

O'Seaghdha, C. M. et al. (2013) Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genetics, 9(9), e1003796. (doi:10.1371/journal.pgen.1003796)

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Abstract

Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in ≤ 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Padmanabhan, Professor Sandosh
Authors: O'Seaghdha, C. M., Wu, H., Yang, Q., Kapur, K., Guessous, I., Zuber, A. M., Köttgen, A., Stoudmann, C., Teumer, A., Kutalik, Z., Mangino, M., Dehghan, A., Zhang, W., Eiriksdottir, G., Li, G., Tanaka, T., Portas, L., Lopez, L. M., Hayward, C., Lohman, K., Matsuda, K., Padmanabhan, S., Firsov, D., Sorice, R., Ulivi, S., Brockhaus, A. C., Kleber, M. E., Mahajan, A., Ernst, F. D., Gudnason, V., Launer, L. J., Mace, A., Boerwinckle, E., Arking, D. E., Tanikawa, C., Nakamura, Y., Brown, M. J., Gaspoz, J.-M., Theler, J.-M., Siscovick, D. S., Psaty, B. M., Bergmann, S., Vollenweider, P., Vitart, V., Wright, A. F., Zemunik, T., Boban, M., Kolcic, I., Navarro, P., Brown, E. M., Estrada, K., Ding, J., Harris, T. B., Bandinelli, S., Hernandez, D., Singleton, A. B., Girotto, G., Ruggiero, D., d'Adamo, A. P., Robino, A., Meitinger, T., Meisinger, C., Davies, G., Starr, J. M., Chambers, J. C., Boehm, B. O., Winkelmann, B. R., Huang, J., Murgia, F., Wild, S. H., Campbell, H., Morris, A. P., Franco, O. H., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Völker, U., Hannemann, A., Biffar, R., Hoffmann, W., Shin, S.-Y., Lescuyer, P., Henry, H., Schurmann, C., Munroe, P. B., Gasparini, P., Pirastu, N., Ciullo, M., Gieger, C., März, W., Lind, L., Spector, T. D., Smith, A. V., Rudan, I., Wilson, J. F., Polasek, O., Deary, I. J., Pirastu, M., Ferrucci, L., Liu, Y., Kestenbaum, B., Kooner, J. S., Witteman, J. C.M., Nauck, M., Kao, W.H. L., Wallaschofski, H., Bonny, O., Fox, C. S., and Bochud, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:PLoS Genetics
Publisher:Public Library of Science
ISSN:1553-7390
ISSN (Online):1553-7390
Copyright Holders:Copyright © 2013 The Authors
First Published:First published PLoS Genetics 9(9):e1003796
Publisher Policy:Reproduced under a Creative Commons License

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