Responding to R-Spondin: Slit2 potentiates intestinal regeneration

Phesse, T. J. and Sansom, O. J. (2013) Responding to R-Spondin: Slit2 potentiates intestinal regeneration. Cell Stem Cell, 13(5), pp. 512-514. (doi:10.1016/j.stem.2013.10.006)

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Abstract

Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature ( Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sansom, Professor Owen
Authors: Phesse, T. J., and Sansom, O. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Stem Cell
ISSN:1934-5909
ISSN (Online):1875-9777

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