Wireless capsule for autofluorescence detection in biological systems

Al-Rawhani, M. A., Beeley, J., Danial, C., Steve, C. and Cumming, D. R.S. (2013) Wireless capsule for autofluorescence detection in biological systems. Sensors and Actuators B: Chemical, 189, pp. 203-207. (doi:10.1016/j.snb.2013.03.037)

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Publisher's URL: http://dx.doi.org/10.1016/j.snb.2013.03.037

Abstract

Variations in tissue autofluorescence (AF) can be exploited to detect early signs of intestinal cancer,however current endoscopic AF systems are only able to inspect the oesophegus and large intestine. Wepresent the design, fabrication and testing of a pill capable of inducing and detecting AF from mammalianintestinal tissue. The prototype comprises an application specific integrated circuit (ASIC), illuminationLED, optical filters to minimise sensor response to crosstalk from the illumination wavelength, a pulsecounter/control unit and a radio transmitter. The ASIC implements a single photon avalanche diodedetector (SPAD), and integrated high voltage (up to 37.9 V) charge pump power supply. The SPAD is biasedabove its breakdown voltage to operate in Geiger mode, and exhibits a detection efficiency peak at 465 nm,sufficiently close to human tissue autofluorescence’s peak of 520 ± 10 nm. The ASIC was fabricated usinga commercial high-voltage CMOS process. The complete device uses an average power of only 21.4 mW.The implemented system has been characterised against controlled solutions of fluorophores and testedin vitro with biological samples. It has been proven to be capable of inducing and detecting fluorescencein fluorophore solution concentration as low as 1 nM, and with mammalian intestinal tissue.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Al-Rawhani, Dr Mohammed and Cumming, Professor David and Beeley, Mr James
Authors: Al-Rawhani, M. A., Beeley, J., Danial, C., Steve, C., and Cumming, D. R.S.
Subjects:T Technology > TK Electrical engineering. Electronics Nuclear engineering
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Research Group:MST
Journal Name:Sensors and Actuators B: Chemical
ISSN:0925-4005
ISSN (Online):1873-3077

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
400041Electronics Design Centre for Heterogeneous SystemsDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/D501288/1ENG - ENGINEERING ELECTRONICS & NANO ENG
387921Extreme sensitivity by engineering plasmon resonance sensorsDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/C509927/1ENG - ENGINEERING ELECTRONICS & NANO ENG
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG