Pulse wave analysis for the prediction of preeclampsia

Carty, D.M., Neisius, U., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2014) Pulse wave analysis for the prediction of preeclampsia. Journal of Human Hypertension, 28(2), pp. 98-104. (doi: 10.1038/jhh.2013.64)

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Preeclampsia is associated with a number of changes to maternal vascular function. Assessment of arterial stiffness using pulse wave analysis (PWA) has been proposed as a means of predicting preeclampsia before the onset of clinically detectable disease. One hundred and eighty women with greater than or equal to2 risk factors for preeclampsia were examined at gestational weeks 16 and 28, of whom 17 (9.4%) developed preeclampsia. To study the effects of pregnancy itself women were also examined at 6–9 months post-natally; an additional 30 healthy non-pregnant women were also examined. PWA was performed using SphygmoCor; augmentation index (AIx), a marker of arterial wave reflection, was also measured using EndoPAT-2000. Women who developed preeclampsia were more likely to be overweight and had a higher brachial and central diastolic BP at gestational week 16 than those who remained normotensive. There was no difference in any parameter of arterial wave reflection between non-pregnant and pregnant women, nor between those who developed preeclampsia and those who remained normotensive, when examined at weeks 16 and 28 or post-natally. In this cohort of women with risk factors for preeclampsia, PWA did not provide additional information beyond brachial blood pressure and maternal risk factor profile about the risk of future development of preeclampsia.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Neisius, Dr Ulf and Rooney, Mrs Laura and Dominiczak, Professor Anna and Delles, Professor Christian and Carty, Dr David
Authors: Carty, D.M., Neisius, U., Rooney, L.K., Dominiczak, A.F., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Journal of Human Hypertension
ISSN (Online):1476-5527

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
595241Cardiovascular consequences of preeclampsia in women from the Generation Scotland: Scottish Family Health Study.Christian DellesScottish Executive Health Department (SEHHD-CSO)ETM/196RI CARDIOVASCULAR & MEDICAL SCIENCES