Green fluorescent diamidines as diagnostic probes for trypanosomes

Giordani, F. , Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi:10.1128/AAC.02024-13)

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Abstract

LED fluorescence microscopy offers potential benefits to the diagnosis of human African trypanosomiasis, as well as to other aspects of diseases management, such as detection of drug resistant strains. To advance such approaches reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we report a series of novel green fluorescent diamidines and their suitability as probes to stain trypanosomes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Giordani, Dr Federica and Barrett, Professor Michael
Authors: Giordani, F., Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W., and Barrett, M. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Antimicrobial Agents and Chemotherapy
Journal Abbr.:Antimicrob Agents Chemother
Publisher:American Society for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Antimicrobial Agents and Chemotherapy 58(3):1793-1796
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
371796The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)085349/Z/08/ZIII - PARASITOLOGY