Centrally inserted external catheters and totally implantable ports for the delivery of chemotherapy: a systematic review and meta-analysis of device-related complications

Kulkarni, S., Wu, O. , Kasthuri, R. and Moss, J.G. (2014) Centrally inserted external catheters and totally implantable ports for the delivery of chemotherapy: a systematic review and meta-analysis of device-related complications. CardioVascular and Interventional Radiology, 37(4), pp. 990-1008. (doi: 10.1007/s00270-013-0771-3)

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Publisher's URL: http://dx.doi.org/10.1007/s00270-013-0771-3

Abstract

<b>Purpose:</b> This systematic review and meta-analysis aimed to evaluate the risks of complications (infectious and non-infectious) including the need for device removal associated with centrally inserted external catheters compared with totally implantable ports in patients undergoing chemotherapy.<p></p> <b>Methods:</b> Relevant major electronic databases were searched from inception to December 2012. All randomized controlled trials (RCT) and observational studies that compared centrally inserted external catheters with totally implantable ports in patients undergoing chemotherapy were included in the systematic review. Meta-analysis was carried out to estimate the odds ratios of device-associated complications, including infection, non-infectious complications and device removal associated with external catheters relative to implantable ports.<p></p> <b>Results:</b> Overall, five RCTs and 25 observational studies were included in the study. The studies were heterogeneous, and included adults and children, with different types of cancer, undergoing chemotherapy. Based on the pooled estimates from included studies, external catheters were associated with approximately a three to four-fold increase in the risks of infections, non-infectious complications and device removal compared implantable ports.<p></p> <b>Conclusion:</b> The findings of this study showed that totally implantable ports are superior to external catheters in terms of catheter-associated complications. However, a formal health technology assessment on the clinical and cost-effectiveness of the use of implantable ports compared with external catheters is needed to inform policy makers of the relative value of investing in totally implantable devices compared with external catheters.<p></p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wu, Professor Olivia and Kasthuri, Dr Ram and Moss, Professor Jonathan
Authors: Kulkarni, S., Wu, O., Kasthuri, R., and Moss, J.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:CardioVascular and Interventional Radiology
Publisher:Springer Link
ISSN:0174-1551
ISSN (Online):1432-086X
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