Autophagy chews Fap to promote apoptosis

Joshi, S. and Ryan, K.M. (2014) Autophagy chews Fap to promote apoptosis. Nature Cell Biology, 16(1), pp. 23-25. (doi:10.1038/ncb2899)

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Abstract

Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Joshi, S., and Ryan, K.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Cell Biology
ISSN:1465-7392
ISSN (Online):1476-4679

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