Joshi, S. and Ryan, K.M. (2014) Autophagy chews Fap to promote apoptosis. Nature Cell Biology, 16(1), pp. 23-25. (doi: 10.1038/ncb2899)
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Abstract
Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ryan, Professor Kevin |
Authors: | Joshi, S., and Ryan, K.M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Nature Cell Biology |
ISSN: | 1465-7392 |
ISSN (Online): | 1476-4679 |
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