Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response

Mair, K.M., Johansen, A.K.Z., Wright, A.F., Wallace, E. and MacLean, M.R. (2014) Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response. British Journal of Pharmacology, 1(3), pp. 567-579. (doi:10.1111/bph.12281)

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Publisher's URL: http://dx.doi.org/10.1111/bph.12281

Abstract

Pulmonary arterial hypertension (PAH) is a complex disease characterized by elevated pulmonary arterial pressure, pulmonary vascular remodelling and occlusive pulmonary vascular lesions, leading to right heart failure. Evidence from recent epidemiological studies suggests the influence of gender on the development of PAH with an approximate female to male ratio of 4:1, depending on the underlying disease pathology. Overall, the therapeutic strategy for PAH remains suboptimal with poor survival rates observed in both genders. Endogenous sex hormones, in particular 17β oestradiol and its metabolites, have been implicated in the development of the disease; however, the influence of sex hormones on the underlying pathobiology remains controversial. Further understanding of the influence of sex hormones on the normal and diseased pulmonary circulation will be critical to our understanding the pathology of PAH and future therapeutic strategies. In this review, we will discuss the influence of sex hormones on the development of PAH and address recent controversies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacLean, Professor Margaret and Johansen, Miss Anne Katrine and Mair, Dr Kirsty
Authors: Mair, K.M., Johansen, A.K.Z., Wright, A.F., Wallace, E., and MacLean, M.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:British Journal of Pharmacology
Journal Abbr.:BJP
Publisher:Wiley
ISSN:0007-1188
ISSN (Online):1476-5381
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
536791Effect of oestrogens and oestrogen metabolites on the serotonin system: role in the development of pulmonary hypertensionMargaret MacleanBritish Heart Foundation (BHF)FS/10/019/28205RI CARDIOVASCULAR & MEDICAL SCIENCES
573731Gender and the development of pulmonary arterial hypertension: regulation of genes from mouse to manMargaret MacleanBritish Heart Foundation (BHF)RG/11/7/28916RI CARDIOVASCULAR & MEDICAL SCIENCES
573733Gender and the development of pulmonary arterial hypertension: regulation of genes from mouse to manMargaret MacleanBritish Heart Foundation (BHF)RG/11/7/28916RI CARDIOVASCULAR & MEDICAL SCIENCES