The virus–receptor interaction in the replication of feline immunodeficiency virus (FIV)

Willett, B.J. and Hosie, M.J. (2013) The virus–receptor interaction in the replication of feline immunodeficiency virus (FIV). Current Opinion in Virology, 3(6), pp. 670-675. (doi: 10.1016/j.coviro.2013.08.003)

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Abstract

The feline and human immunodeficiency viruses (FIV and HIV) target helper T cells selectively, and in doing so they induce a profound immune dysfunction. The primary determinant of HIV cell tropism is the expression pattern of the primary viral receptor CD4 and co-receptor(s), such as CXCR4 and CCR5. FIV employs a distinct strategy to target helper T cells; a high affinity interaction with CD134 (OX40) is followed by binding of the virus to its sole co-receptor, CXCR4. Recent studies have demonstrated that the way in which FIV interacts with its primary receptor, CD134, alters as infection progresses, changing the cell tropism of the virus. This review examines the contribution of the virus–receptor interaction to replication in vivo as well as the significance of these findings to the development of vaccines and therapeutics.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian
Authors: Willett, B.J., and Hosie, M.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Virology
ISSN:1879-6257
ISSN (Online):1879-6265

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