Secreted wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients

Ueland, T., Rollag, H., Hartmann, A., Jardine, A.G. , Humar, A., Michelsen, A.E., Bignamini, A.A., Åsberg, A. and Aukrust, P. (2014) Secreted wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients. American Journal of Transplantation, 14(1), pp. 210-215. (doi: 10.1111/ajt.12506)

Abstract

We evaluated secreted wingless (Wnt) modulators during cytomegalovirus (CMV) infection in solid organ transplant recipients (SOTr). The major findings were: (i) Plasma levels of Dickkopf-1 (DKK-1) were significantly lower in patients with CMV DNAemia above lower level of quantification at baseline. (ii) Receiver operating characteristic analysis indicated that low DKK-1 and increased secreted frizzled related protein-3 levels were predictors of poor virological outcomes during follow-up. Our findings demonstrate an imbalanced pattern of circulating secreted Wnt modulators in SOTr with poor virological outcomes following treatment for CMV disease, and may suggest a role for dysregulated Wnt signaling on viral pathogenesis during CMV infection.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Jardine, Professor Alan
• Authors: Ueland, T., Rollag, H., Hartmann, A., Jardine, A.G., Humar, A., Michelsen, A.E., Bignamini, A.A., Åsberg, A., and Aukrust, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: American Journal of Transplantation
• Publisher: Wiley-Blackwell Publishing, Inc.
• ISSN: 1600-6135
• ISSN (Online): 1600-6143