Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation?

Özçaka, Ö., Buduneli, N., Ceyhan, B.O., Akcali, A., Hannah, V., Nile, C. and Lappin, D.F. (2013) Is interleukin-17 involved in the interaction between polycystic ovary syndrome and gingival inflammation? Journal of Periodontology, 84(12), pp. 1827-1837. (doi: 10.1902/jop.2013.120483)

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a hormonal disorder of females of reproductive age that impacts their oral and systemic health. The aim of this study is to evaluate interleukin-17A (IL-17A), IL-17F, IL-17A/F, and IL-17E (IL-25) levels in gingival crevicular fluid (GCF), saliva, and serum of non-obese females with PCOS and with either a clinically healthy periodontium or gingivitis.<p></p> Methods: Thirty-one females with PCOS, 30 females with PCOS and gingivitis, and 12 systemically and periodontally healthy females participated in the study. Clinical periodontal measurements, body mass index, and Ferriman-Gallwey score (FGS) (a measure of hirsutism in females) were recorded. Circulating levels of sex hormones, cortisol, and insulin were also determined. Levels of IL-17 cytokines were measured by enzyme-linked immunosorbent assay.<p></p> Results: The general linear model multivariate analysis, adjusting for age or plaque index, showed that the two groups with PCOS had higher concentrations of IL-17A, IL-17F, and IL-17A/F in serum and higher levels of IL-17A and IL-17F in GCF and saliva but lower serum IL-17E than systemically healthy females. Levels of IL-17E were lowest in females with PCOS and gingivitis who also had the highest FGS. Serum IL-17A and IL-17F levels correlated positively with FGS and periodontal probing depth (all ρ >0.33; P <0.005). Serum IL-17E showed the reverse relationship and also correlated negatively with IL-17A (ρ >−0.28; P <0.05).<p></p> Conclusions: IL-17 levels are altered in non-obese females with PCOS and may influence gingival inflammation. Additional studies are warranted to clarify the relationship between PCOS and gingivitis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lappin, Dr David and Harper, Dr Victoria and Nile, Dr Christopher
• Authors: Özçaka, Ö., Buduneli, N., Ceyhan, B.O., Akcali, A., Hannah, V., Nile, C., and Lappin, D.F.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Journal of Periodontology
• ISSN: 0022-3492
• ISSN (Online): 1943-3670