Single bubble acoustic characterization and stability measurement of adherent microbubbles

Casey, J., Sennoga, C., Mulvana, H. , Hajnal, J.V., Tang, M.-X. and Eckersley, R.J. (2013) Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound in Medicine and Biology, 39(5), pp. 903-914. (doi: 10.1016/j.ultrasmedbio.2012.12.007)

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Abstract

This article examines how the acoustic and stability characteristics of single lipid-shelled microbubbles (MBs) change as a result of adherence to a target surface. For individual adherent and non-adherent MBs, the backscattered echo from a narrowband 2-MHz, 90-kPa peak negative pressure interrogation pulse was obtained. These measurements were made in conjunction with an increasing amplitude broadband disruption pulse. It was found that, for the given driving frequency, adherence had little effect on the fundamental response of an MB. Examination of the second harmonic response indicated an increase of the resonance frequency for an adherent MB: resonance radius increasing of 0.3 ± 0.1 μm for an adherent MB. MB stability was seen to be closely related to MB resonance and gave further evidence of a change in the resonance frequency due to adherence.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mulvana, Dr Helen
Authors: Casey, J., Sennoga, C., Mulvana, H., Hajnal, J.V., Tang, M.-X., and Eckersley, R.J.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Ultrasound in Medicine and Biology
Publisher:Elsevier
ISSN:0301-5629
ISSN (Online):1879-291X

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