Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling

McKinney, C. A., Fattah, C., Loughrey, C. M. , Milligan, G. and Nicklin, S. A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126, pp. 815-827. (doi:10.1042/CS20130436)

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Publisher's URL: http://dx.doi.org/10.1042/CS20130436

Abstract

The renin angiotensin system (RAS) is integral to cardiovascular physiology, however, dysregulation of this system largely contributes to the pathophysiology of cardiovascular disease (CVD). It is well established that angiotensin II (Ang II), the main effector of the RAS, engages the angiotensin type 1 receptor and promotes cell growth, proliferation, migration and oxidative stress, all processes which contribute to remodeling of the heart and vasculature, ultimately leading to the development and progression of various CVDs including heart failure and atherosclerosis. The counter-regulatory axis of the RAS, which is centered on the actions of angiotensin converting enzyme 2 (ACE2) and the resultant production of angiotensin-(1-7) (Ang-(1-7) from Ang II, antagonizes the actions of Ang II via the receptor Mas, thereby providing a protective role in CVD. More recently, another ACE2 metabolite, Ang-(1-9), has been reported to be a biologically active peptide within the counter-regulatory axis of the RAS. This review will discuss the role of the counter-regulatory RAS peptides, Ang-(1-7) and Ang-(1-9) in the cardiovascular system, with a focus on their effects in remodeling of the heart and vasculature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nicklin, Professor Stuart and Milligan, Professor Graeme and Loughrey, Dr Christopher
Authors: McKinney, C. A., Fattah, C., Loughrey, C. M., Milligan, G., and Nicklin, S. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Clinical Science
Publisher:Portland Press Ltd.
ISSN:0143-5221
ISSN (Online):1470-8736
Copyright Holders:Copyright © 2104 Portland Press
First Published:First published in Clinical Science 126:815-827
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
570291Angiotensin 1-9 and angiotensin 1-7: assessment of their mechanisms of action as counter-regulatory renin angiotensin system peptides in cardiovascular diseaseStuart NicklinBritish Heart Foundation (BHF)PG/11/43/28901RI CARDIOVASCULAR & MEDICAL SCIENCES
519461Dissecting the mechanism of action of the novel renin angiotensin hormone angiotensin1-9Stuart NicklinMedical Research Council (MRC)G0901161RI CARDIOVASCULAR & MEDICAL SCIENCES