Non-structural proteins of arthropod-borne bunyaviruses: roles and functions

Eifan, S., Schnettler, E., Dietrich, I., Kohl, A. and Blomstrom, A. (2013) Non-structural proteins of arthropod-borne bunyaviruses: roles and functions. Viruses, 5(10), pp. 2447-2468. (doi:10.3390/v5102447)

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Abstract

Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Schnettler, Dr Esther and Blomstrom, Dr Anne-Lie and Dietrich, Dr Isabelle and Kohl, Professor Alain
Authors: Eifan, S., Schnettler, E., Dietrich, I., Kohl, A., and Blomstrom, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
Publisher:MDPI
ISSN:1999-4915
ISSN (Online):1999-4915
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Viruses 5(10):2477-2468
Publisher Policy:Reproduced under a Creative Commons License

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