Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)
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Abstract
Insects successfully occupy most environmental niches and this success depends on surviving a broad range of environmental stressors including temperature, desiccation, xenobiotic, osmotic and infection stress. Epithelial tissues play key roles as barriers between the external and internal environments and therefore maintain homeostasis and organismal tolerance to multiple stressors. As such, the crucial role of epithelia in organismal stress tolerance cannot be underestimated. At a molecular level, multiple cell-specific signalling pathways including cyclic cAMP, cyclic cGMP and calcium modulate tissue, and hence, organismal responses to stress. Thus, epithelial cell-specific signal transduction can be usefully studied to determine the molecular mechanisms of organismal stress tolerance in vivo. This review will explore cell signalling modulation of stress tolerance in insects by focusing on cell signalling in a fluid transporting epithelium – the Malpighian tubule. Manipulation of specific genes and signalling pathways in only defined tubule cell types can influence the survival outcome in response to multiple environmental stressors including desiccation, immune, salt (ionic) and oxidative stress, suggesting that studies in the genetic model Drosophila melanogaster may reveal novel pathways required for stress tolerance.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cabrero, Mr Pablo and Dow, Professor Julian and Aitchison, Miss Lorriane and Sebastian, Mr Sujith and Terhzaz, Dr Selim and Davies, Professor Shireen and Overend, Dr Gayle |
Authors: | Davies, S.A., Cabrero, P., Overend, G., Aitchison, L., Sebastian, S., Terhzaz, S., and Dow, J.A.T. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Journal of Experimental Biology |
ISSN: | 0022-0949 |
ISSN (Online): | 1477-9145 |
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