Use of tamoxifen in the control of canine mammary neoplasia

Morris, J. , Dobson, J.M. and Bostock, D.E. (1993) Use of tamoxifen in the control of canine mammary neoplasia. Veterinary Record, 133(22), pp. 539-542. (doi:10.1136/vr.133.22.539)

Morris, J. , Dobson, J.M. and Bostock, D.E. (1993) Use of tamoxifen in the control of canine mammary neoplasia. Veterinary Record, 133(22), pp. 539-542. (doi:10.1136/vr.133.22.539)

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Abstract

Ninety-three bitches which had undergone mammary tumour surgery were entered into a clinical trial to examine the effects of ovariohysterectomy (spaying) at the time of mammary surgery and the use of the drug tamoxifen in preventing the recurrence of the tumour and/or the development of new mammary tumours. Twenty-three of the bitches which had been spayed were allocated tamoxifen but only 18 of them complied with the treatment and in nine of these the treatment was stopped owing to side effects (mostly oestrogenic). Too few animals were studied to draw conclusions about the possible preventative effects of tamoxifen on mammary neoplasia, but the high percentage of bitches affected by oestrogen-like side effects may reduce the compliance of owners and prevent tamoxifen being widely used in dogs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morris, Professor Joanna
Authors: Morris, J., Dobson, J.M., and Bostock, D.E.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Record
Publisher:B M J Group
ISSN:0042-4900
ISSN (Online):2042-7670

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