Neto, H., Kaupisch, A., Collins, L.L. and Gould, G.W. (2013) Syntaxin 16 is a master recruitment factor for cytokinesis. Molecular Biology of the Cell, 24(23), pp. 3663-3674. (doi: 10.1091/mbc.E13-06-0302) (PMID:24109596) (PMCID:PMC3842993)
|
Text
89050.pdf - Published Version Available under License Creative Commons Attribution. 2MB |
Abstract
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome–associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Collins, Dr Louise and Kaupisch, Dr Alexandra and Neto, Dr Helia and Gould, Professor Gwyn |
Authors: | Neto, H., Kaupisch, A., Collins, L.L., and Gould, G.W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Molecular Biology of the Cell |
Publisher: | American Society for Cell Biology |
ISSN: | 1059-1524 |
ISSN (Online): | 1939-4586 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in Molecular Biology of the Cell 24(23):3663-3674 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record