Syntaxin 16 is a master recruitment factor for cytokinesis

Neto, H., Kaupisch, A., Collins, L.L. and Gould, G.W. (2013) Syntaxin 16 is a master recruitment factor for cytokinesis. Molecular Biology of the Cell, 24(23), pp. 3663-3674. (doi: 10.1091/mbc.E13-06-0302) (PMID:24109596) (PMCID:PMC3842993)

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Abstract

Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmalei­mide–sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome–associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn and Collins, Dr Louise and Kaupisch, Dr Alexandra and Neto, Dr Helia
Authors: Neto, H., Kaupisch, A., Collins, L.L., and Gould, G.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Molecular Biology of the Cell
Publisher:American Society for Cell Biology
ISSN:1059-1524
ISSN (Online):1939-4586
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Molecular Biology of the Cell 24(23):3663-3674
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
463021Regulation and role of the Exocyst complex in cytokinesis.Gwyn GouldCancer Research UK (CAN-RES-UK)C25017/A9006RI MOLECULAR CELL & SYSTEMS BIOLOGY
562531Investigation of the role of Syntaxin 16 and mVps45 in cytokinesisGwyn GouldCancer Research UK (CAN-RES-UK)13082RI MOLECULAR CELL & SYSTEMS BIOLOGY