Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing

Pathai, S., Shiels, P.G. , Weiss, H.A., Gilbert, C.E., Peto, T., Bekker, L., Wood, R., Wong, T.Y. and Lawn, S.D. (2013) Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. Mechanisms of Ageing and Development, 134(9), pp. 400-406. (doi:10.1016/j.mad.2013.08.002)

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Abstract

HIV-infected individuals have an increased risk of age-related morbidity despite antiretroviral treatment (ART). Several anatomic and functional ophthalmological parameters are associated with increasing chronological age. These may, therefore, potentially serve as biomarkers of ageing. We investigated associations between ocular parameters (lens density, retinal vessel calibre, corneal endothelium and retinal nerve fibre layer thickness) and two ‘cellular’ biomarkers of ageing (leukocyte telomere length and CDKN2A expression) and with frailty in a cross-sectional study of 216 HIV-infected individuals. All ocular parameters, telomere length and frailty were associated with chronological age, whereas CDKN2A expression was not. Retinal venular calibre and lens density were associated with shorter telomere length (p-trend = 0.04, and 0.08, respectively), whereas CDKN2A expression and frailty status were not associated with ocular parameters. Longitudinal studies are warranted to assess the integration of retinal vascular calibre and lens density with systemic markers to develop an overall index of biological ageing in HIV infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Pathai, S., Shiels, P.G., Weiss, H.A., Gilbert, C.E., Peto, T., Bekker, L., Wood, R., Wong, T.Y., and Lawn, S.D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Mechanisms of Ageing and Development
Publisher:Elsevier Ireland Ltd
ISSN:0047-6374
ISSN (Online):1872-6216

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