MicroRNAs in pulmonary arterial remodeling

Grant, J. S., White, K., MacLean, M. R. and Baker, A. H. (2013) MicroRNAs in pulmonary arterial remodeling. Cellular and Molecular Life Sciences, 70(23), pp. 4479-4494. (doi: 10.1007/s00018-013-1382-5)

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Publisher's URL: http://dx.doi.org/10.1007/s00018-013-1382-5

Abstract

Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular remodeling leading to intimal lesions, resulting in elevated pulmonary vascular resistance and right heart dysfunction. Mutations within the bone morphogenetic protein receptor 2 gene, leading to dysregulated proliferation of pulmonary artery smooth muscle cells, have been identified as being responsible for heritable PAH. Indeed, the disease is characterized by excessive cellular proliferation and resistance to apoptosis of smooth muscle and endothelial cells. Significant gene dysregulation at the transcriptional and signaling level has been identified. MicroRNAs are small non-coding RNA molecules that negatively regulate gene expression and have the ability to target numerous genes, therefore potentially controlling a host of gene regulatory and signaling pathways. The major role of miRNAs in pulmonary arterial remodeling is still relatively unknown although research data is emerging apace. Modulation of miRNAs represents a possible therapeutic target for altering the remodeling phenotype in the pulmonary vasculature. This review will focus on the role of miRNAs in regulating smooth muscle and endothelial cell phenotypes and their influence on pulmonary remodeling in the setting of PAH.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacLean, Professor Margaret and Baker, Professor Andrew and White, Dr Kevin
Authors: Grant, J. S., White, K., MacLean, M. R., and Baker, A. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cellular and Molecular Life Sciences
Publisher:Springer Basel
ISSN:1420-682X
ISSN (Online):1420-9071
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Cellular and Molecular Life Sciences 70(23):4479-4494
Publisher Policy:Reproduced under a Creative Commons License
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