Molecular triggers of neuroinflammation in mouse models of demyelinating diseases

Barrette, B., Nave, K.-A. and Edgar, J.M. (2013) Molecular triggers of neuroinflammation in mouse models of demyelinating diseases. Biological Chemistry, 394(12), (doi: 10.1515/hsz-2013-0219)

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Abstract

Myelinating cells wrap axons with multi-layered myelin sheaths for rapid impulse propagation. Dysfunctions of oligodendrocytes or Schwann cells are often associated with neuroinflammation, as observed in animal models of leukodystrophies and peripheral neuropathies, respectively. The neuroinflammatory response modulates the pathological changes, including demyelination and axonal injury, but also remyelination and repair. Here we discuss different immune mechanisms as well as factors released or exposed by myelinating glia in disease conditions. The spectrum of inflammatory mediators varies with different myelin disorders and has a major impact on the beneficial or detrimental role of immune cells in keeping nervous system integrity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Edgar, Professor Julia
Authors: Barrette, B., Nave, K.-A., and Edgar, J.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Biological Chemistry
ISSN:1431-6730
ISSN (Online):1437-4315

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