Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma

Frampton, M. et al. (2013) Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma. Nature Communications, 4(2549), (doi:10.1038/ncomms3549)

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Abstract

n addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarrett, Professor Ruth and Montgomery, Mrs Dorothy and Lake, Ms Annette
Authors: Frampton, M., da Silva Filho, M.I., Broderick, P., Thomsen, H., Försti, A., Vijayakrishnan, J., Cooke, R., Enciso-Mora, V., Hoffmann, P., Nöthen, M.M., Lloyd, A., Holroyd, A., Eisele, L., Jöckel, K., Ponader, S., von Strandmann, E.P., Lightfoot, T., Roman, E., Lake, A., Montgomery, D., Jarrett, R.F., Swerdlow, A.J., Engert, A., Hemminki, K., and Houlston, R.S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Communications
Publisher:Nature Publishing Group
ISSN:2041-1723
ISSN (Online):2041-1723

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